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Molecular machine could develop drugs for bioweapons victims
@ Biotechnology
Oct 01 2002, 09:49 (UTC+0) | BenEdIctuM writes: Researchers at the Department of Energy's Los Alamos National Laboratory have created the first computer model of a key part of the E-coli ribosome, a cellular structure responsible for the creation of proteins, that has applications in the development of new and powerful antibiotics for use in the treatment of illnesses caused by all pathogens, including a host of bioweapons agents. A ribosome's function in a biological system is to de-code the instructions in the cell's DNA for making proteins, essential for the growth and survival of the cell. Many antibiotic drugs work by forcing the ribosomes of disease-causing microorganisms to malfunction, killing the microorganism and curing the disease. The Los Alamos model, the largest atomic-level asymmetrical biomolecular complex ever modeled - identifying the position of approximately 90,000 individual atoms - was developed by Chang-Shung Tung and Kevin Sanbonmatsu of the Lab's Theoretical Biology and Biophysics group and Simpson Joseph of the University of California, San Diego. ...Read More... |
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